Cytokine release syndrome (CRS)

Cytokine Release Syndrome (CRS) is a common side effect of CAR T-cell therapy and is related to the way the treatment works.

It occurs when CAR T-cells cause the body to have an inflammatory response. The body releases large amounts of cytokines (proteins) into the bloodstream from immune cells affected by the treatment.

It’s important to receive treatment for CRS as soon as possible. Your healthcare team will monitor you closely and will help to identify if you are having a reaction. If you do experience more severe side effects, you may be moved to the Intensive Care Unit (ICU) to ensure you get the best possible care. More information on the ICU can be found here.

With treatment, the majority of patients are successfully treated for CRS.

Tell your doctor or healthcare team straight away if you notice any of the following signs and symptoms:

Fever (e.g., temperature above 38°C)

Light-headedness

Dizziness

Low blood pressure

Shortness of breath

Rapid heartbeat

Chills

Extreme tiredness

Weakness

Headache

Cough